Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes Leishmania infantum promastigotes. U. showed against both parasites with IC50 values 7 µg/mL 31 µg/mL, respectively. Fractionation led to isolation euparin, jaceidin, santhemoidin C, eucannabinolide. sesquiterpene lactones eucannabinolide C active T. 10 ± 2 µM (4.2 µg/mL) 18 3 (7.6 µg/mL), Euparin most L. 4 (3.9 19 (8.0 Eucannabinolide has also shown drug-like pharmacokinetic toxicity properties.